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  • Ziv Zwighaft

BPL Biologics diversivied services

Updated: Jun 24

CLIENT TYPE:

US Biotech / licensed IP from UK academic instutute


EXPRESSION SYSTEM:

CHO


PRODUCT – INTENDED USE:

Growth factor (injectable); anti-cancer therapeutic


SCOPE OF WORK / PROJECT HIGHLIGHTS:

· Upstream process development and scale up to 5L bioreactor

· Purification process development and scale up

· Production and release of multiples batches for pre-clinical use

· Technology transfer to US based CM


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CLIENT TYPE:

Fortune 500 diagnostics company

EXPRESSION SYSTEM:

CHO

PRODUCT – INTENDED USE:

Mab for diagnostic; use in IVD kit

SCOPE OF WORK / PROJECT HIGHLIGHTS:

· Set up and qualificatio of analytical methods

· Development of purification process

· Audit by global company prior to GMP production

· Release of multiple GMP batches to supply production of diagnostic kits


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CLIENT TYPE:

FP-7 European consortium

EXPRESSION SYSTEM:

E.Coli

PRODUCT – INTENDED USE:

Growth factor; small protein; intended for injection


SCOPE OF WORK / PROJECT HIGHLIGHTS:

· Clone development and supply thru pre-clinical and clinical studies

· Plasmid to express fusion protein in soluble fraction; followed by cleavage

· Clone preparation and GMP grade Master Cell Bank

· Development of upstream process and scale up to 20L

· Development of recovery process and purification

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CLIENT TYPE:

Local Biotech / IP licensed from academia

EXPRESSION SYSTEM:

E.Coli

PRODUCT – INTENDED USE:

Enzyme; injectable; Stroke indication; glutamate scavenger

SCOPE OF WORK / PROJECT HIGHLIGHTS:

· Preparation of clone and Pre-MCB

· Set up analytical methods

· Development of upstream process and scale up to 20L fermenter

· Development of recovery purification processes and scale up

· Production of multiple batches to supply pre-clinical studies


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CLIENT TYPE:

Fortune 500 pharma company


EXPRESSION SYSTEM:

Plasma

PRODUCT – INTENDED USE:

Antibodies for use in ELISA and Western Blot


SCOPE OF WORK / PROJECT HIGHLIGHTS:

· Antibody purification from variety of plasma sources: porcine, sheep, horse, goat, rabbit

· Set up analytical methods

· Development of purification process - high yield, high purity and high specificity

· Preparation of batches and release for use

· Transfer of technology to customer


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CLIENT TYPE:

Israeli biotech, NYSE


EXPRESSION SYSTEM:

Plasma

PRODUCT – INTENDED USE:

mAb used in ELISA and Western Blot; for QC release of commercial product


SCOPE OF WORK / PROJECT HIGHLIGHTS:

· Antibodies derived from sheep plasma

· Set up analytical methods

· Development of purification process with high yield, high purity and high specificity

· Preparation of batches and release for use

· Transfer of technology to customer


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