- Ziv Zwighaft
BPL Biologics diversivied services
Updated: Jun 24, 2020
CLIENT TYPE:
US Biotech / licensed IP from UK academic instutute
EXPRESSION SYSTEM:
CHO
PRODUCT – INTENDED USE:
Growth factor (injectable); anti-cancer therapeutic
SCOPE OF WORK / PROJECT HIGHLIGHTS:
· Upstream process development and scale up to 5L bioreactor
· Purification process development and scale up
· Production and release of multiples batches for pre-clinical use
· Technology transfer to US based CM
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CLIENT TYPE:
Fortune 500 diagnostics company
EXPRESSION SYSTEM:
CHO
PRODUCT – INTENDED USE:
Mab for diagnostic; use in IVD kit
SCOPE OF WORK / PROJECT HIGHLIGHTS:
· Set up and qualificatio of analytical methods
· Development of purification process
· Audit by global company prior to GMP production
· Release of multiple GMP batches to supply production of diagnostic kits
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CLIENT TYPE:
FP-7 European consortium
EXPRESSION SYSTEM:
E.Coli
PRODUCT – INTENDED USE:
Growth factor; small protein; intended for injection
SCOPE OF WORK / PROJECT HIGHLIGHTS:
· Clone development and supply thru pre-clinical and clinical studies
· Plasmid to express fusion protein in soluble fraction; followed by cleavage
· Clone preparation and GMP grade Master Cell Bank
· Development of upstream process and scale up to 20L
· Development of recovery process and purification
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CLIENT TYPE:
Local Biotech / IP licensed from academia
EXPRESSION SYSTEM:
E.Coli
PRODUCT – INTENDED USE:
Enzyme; injectable; Stroke indication; glutamate scavenger
SCOPE OF WORK / PROJECT HIGHLIGHTS:
· Preparation of clone and Pre-MCB
· Set up analytical methods
· Development of upstream process and scale up to 20L fermenter
· Development of recovery purification processes and scale up
· Production of multiple batches to supply pre-clinical studies
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CLIENT TYPE:
Fortune 500 pharma company
EXPRESSION SYSTEM:
Plasma
PRODUCT – INTENDED USE:
Antibodies for use in ELISA and Western Blot
SCOPE OF WORK / PROJECT HIGHLIGHTS:
· Antibody purification from variety of plasma sources: porcine, sheep, horse, goat, rabbit
· Set up analytical methods
· Development of purification process - high yield, high purity and high specificity
· Preparation of batches and release for use
· Transfer of technology to customer
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CLIENT TYPE:
Israeli biotech, NYSE
EXPRESSION SYSTEM:
Plasma
PRODUCT – INTENDED USE:
mAb used in ELISA and Western Blot; for QC release of commercial product
SCOPE OF WORK / PROJECT HIGHLIGHTS:
· Antibodies derived from sheep plasma
· Set up analytical methods
· Development of purification process with high yield, high purity and high specificity
· Preparation of batches and release for use
· Transfer of technology to customer